Yellow Jack is a 1938 film released by Metro-Goldwyn-Mayer based on the 1934 play Yellow Jack. Both were co-written by Sidney Howard and Paul de Kruif (the former a Pulitzer- and Oscar-winning playwright and screenwriter; the latter a well-known microbiologist and author).

Produced and directed by the legendary Guthrie McClintic, the original Broadway play co-starred James Stewart and Sam Levene and opened at the Martin Beck Theatre, March 6, 1934. Stewart's performance as Sergeant John O'Hara in the Broadway production of Yellow Jack attracted the attention of Hollywood along with a MGM contract. When Yellow Jack was filmed, Stewart was unavailable and replaced by Robert Montgomery. Sam Levene was the only member of the original Broadway cast to also appear in the movie. The supporting cast also features Lewis Stone, Andy Devine, Henry Hull, Charles Coburn and Buddy Ebsen.